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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RB1 All Species: 26.67
Human Site: S888 Identified Species: 48.89
UniProt: P06400 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06400 NP_000312.2 928 106159 S888 G S D E A D G S K H L P G E S
Chimpanzee Pan troglodytes XP_509777 1075 122190 S1035 G S D E A D G S K H L P G E S
Rhesus Macaque Macaca mulatta XP_001100383 928 106126 S888 G S D E A D G S K H L P G E S
Dog Lupus familis XP_534118 897 103170 S857 G S D E A D G S K H L P G E S
Cat Felis silvestris
Mouse Mus musculus P13405 921 105320 S881 G A D E A D G S K H L P A E S
Rat Rattus norvegicus P33568 920 105007 S880 G S D E A D G S K H L P A E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514098 917 104520 S877 G Q D E A D G S K H L P G E S
Chicken Gallus gallus Q90600 921 104417 G881 G Q D E A D G G K H L P Q E S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001071248 903 102339 G864 D G Q D E A D G S K S S G E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395096 1006 113492 K965 D P K R S V G K R L L S D D T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790323 774 86478 T735 L P H A L S Q T Y K N V Y M G
Poplar Tree Populus trichocarpa B9GLX8 1035 114624 N996 R K A R G T L N L D N D V G L
Maize Zea mays Q3LXA7 1010 111475 R970 G G K K V S G R L N F D V V S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.2 99.3 90 N.A. 90.4 89.7 N.A. 81.3 73 N.A. 53.9 N.A. N.A. 23 N.A. 26.4
Protein Similarity: 100 86.3 99.5 93 N.A. 94.9 95.1 N.A. 88.2 84.1 N.A. 70.9 N.A. N.A. 42.9 N.A. 42.6
P-Site Identity: 100 100 100 100 N.A. 86.6 93.3 N.A. 93.3 80 N.A. 20 N.A. N.A. 13.3 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 80 N.A. 26.6 N.A. N.A. 40 N.A. 6.6
Percent
Protein Identity: 22.1 23.2 N.A. N.A. N.A. N.A.
Protein Similarity: 40.4 42.1 N.A. N.A. N.A. N.A.
P-Site Identity: 0 20 N.A. N.A. N.A. N.A.
P-Site Similarity: 6.6 33.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 62 8 0 0 0 0 0 0 16 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 62 8 0 62 8 0 0 8 0 16 8 8 0 % D
% Glu: 0 0 0 62 8 0 0 0 0 0 0 0 0 70 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 70 16 0 0 8 0 77 16 0 0 0 0 47 8 8 % G
% His: 0 0 8 0 0 0 0 0 0 62 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 16 8 0 0 0 8 62 16 0 0 0 0 0 % K
% Leu: 8 0 0 0 8 0 8 0 16 8 70 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 8 16 0 0 0 0 % N
% Pro: 0 16 0 0 0 0 0 0 0 0 0 62 0 0 0 % P
% Gln: 0 16 8 0 0 0 8 0 0 0 0 0 8 0 0 % Q
% Arg: 8 0 0 16 0 0 0 8 8 0 0 0 0 0 0 % R
% Ser: 0 39 0 0 8 16 0 54 8 0 8 16 0 0 77 % S
% Thr: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 8 % T
% Val: 0 0 0 0 8 8 0 0 0 0 0 8 16 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _